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About Pharmacogenetics and the Inagene Program
What is pharmacogenetic (PGx) testing?
Pharmacogenetic testing analyzes the specific genes that determine how a person's body processes medications. Different people metabolize drugs differently based on their genetics: some break down a medication too quickly for it to be effective, others too slowly, causing side effects or toxicity. A PGx test identifies these variations and translates them into clear, clinically actionable guidance for prescribers. The result is a genetic roadmap that informs medication decisions going forward.
How is Inagene different from other PGx tests?
Several factors distinguish Inagene from other pharmacogenetic programs available in Canada. Inagene's panel covers 48 genes and 123 variants (and growing) - the most comprehensive available in Canada. From an equity standpoint, Inagene pays particular attention to genetic variants that affect diverse populations that narrower panels routinely miss. All testing is conducted in Inagene's own Canadian laboratory, independently accredited to the highest international standards. Inagene's medication database is updated regularly as new evidence emerges. Moreover, Inagene is a complete program meant to help the plan ecosystem: account management, member engagement support, and plan-level outcomes reporting are all built in.
Which medications and conditions does Inagene cover?
Inagene's panel currently covers 240+ commonly prescribed medications across mental health (antidepressants, antipsychotics, ADHD medications), chronic pain (opioids, anti-inflammatories, nerve pain treatments), cardiovascular health (blood thinners, statins, blood pressure medications), women's health (birth control, menstrual pain, PMDD, HRT), neurology, gastrointestinal conditions, and more. The database is updated quarterly as new medication-gene associations meet rigorous evidence thresholds.
How does the testing process work?
A member receives a simple at-home cheek swab kit. They complete the swab and return it to Inagene's Canadian laboratory using the prepaid return envelope included. Results are delivered within 7–10 business days through a secure portal accessible to both the member and their treating clinician. The member can also request a consultation with one of Inagene's licensed pharmacists to walk through their results and discuss implications for their current or future medications.
Will members need to be retested?
A person's genetic makeup does not change, so the results of a PGx test remain clinically relevant for the genes and medications already tested. Inagene's medication-gene database is updated quarterly as new evidence emerges, and existing results continue to grow in relevance over time without any action needed from the member. As Inagene's panel expands to cover additional genes, a new sample may eventually be needed to provide guidance specific to those newly added genes.
Privacy, Data Security, and Compliance
Will employers or plan administrators have access to member genetic results?
Never. Member genetic results go directly to the member and their treating clinician. Employers, plan sponsors, insurers, TPAs, and disability management organizations do not have access to individual member results under any circumstances. The only aggregate data shared with plan administrators are utilization rates and general outcomes trends which contains no individual identifying information. This separation is a foundational principle of how Inagene operates.
Where is member genetic data stored, and who has access to it?
All member genetic data is stored in Canadian data centers and processed in Inagene's own Canadian laboratory. Data never leaves Canadian jurisdiction. Inagene operates in compliance with applicable Canadian federal and provincial privacy legislation, and all data handling is governed by Inagene's privacy framework. No third party has access to member genetic data without explicit member consent.
Does genetic testing affect a member's insurance coverage?
No. Canadian law prohibits insurers and employers from using genetic test results to make decisions about coverage, premiums, or employment. Members can complete Inagene's test with full confidence that their results will not affect their insurance status or employment in any way. Inagene recommends that organization use our promotional materials to communicate this early and clearly to members as part of the program launch.
Implementation, Integration, and Results
How does Inagene integrate into an existing benefit plan or disability management program?
Inagene is designed to complement existing programs rather than replace or disrupt them. For benefit plans, Inagene can be added as a managed benefit with member communications and utilization support handled by Inagene's account management team, which will minimize administrative lift for the plan sponsor or TPA. For disability management programs, Inagene integrates at the case manager level as part of their workflow: when a case manager identifies medication response as a likely barrier to recovery, a simple referral initiates the process. Results go directly to the member and their treating clinician, with no additional work for the case management team.
What kind of results can organizations expect?
Results vary by population and program design, but the clinical evidence and early program data point to meaningful impact across three areas: reduced medication trial-and-error (and the associated drug spend waste), shorter disability claim duration for cases where medication ineffectiveness is a contributing factor, and improved member outcomes as prescribers make more informed decisions. Inagene provides anonymized, plan-level data reporting on an ongoing basis so organizations can track program impact over time.
How long does it take to implement the program?
Implementation timeline varies depending on the organization type and scope of deployment. Inagene's account management team works with each partner organization to design the program, develop member communications, train relevant staff, and establish check-in and reporting cadences before launch. Most implementations can be completed within a few weeks of agreement. Contact us to discuss a timeline specific to your organization.
What support does Inagene provide after launch?
Ongoing account management is built into every Inagene program. After launch, Inagene provides continued member engagement support and communications, utilization tracking, program performance reporting, and access to updated resources as the medication database grows. Organizations are not left to drive adoption on their own.
Other Questions
We already offer PGx coverage through our insurer. Why would we need Inagene?
Voluntary PGx coverage, where members claim reimbursement for a test they would seek out themselves, typically generates very low utilization. The members who would benefit most from pharmacogenetic guidance rarely seek it out proactively, which means the clinical and financial value of the coverage goes largely unrealized. Inagene's managed program is designed to actively reach the right members at the right time, with account management and member communications support that drives meaningful utilization rather than passive availability.
As a benefits consultant, how do I present Inagene to my plan sponsor clients?
Inagene supports benefits consultants with the materials and knowledge needed to have confident conversations with plan sponsor clients, including plan-level modeling, case study data, and presentation support. The core conversation is straightforward: rising drug costs and disability claims have a root cause that existing programs don't address, and Inagene is the upstream intervention that changes that equation. Contact us to discuss how we can support your next client conversation.
How does Inagene work within a disability management workflow specifically?
When a case manager encounters a claim that is stalling despite appropriate care and a solid return-to-work plan in place, they may identify medication response as a likely barrier to recovery. In this case they can initiate a referral to Inagene. The member receives a test kit, completes the swab at home, and results are delivered to the member and their treating clinician within 7–10 business days. The case manager is notified that the process is underway and can follow up with the treating clinician to ensure results are being actioned. The entire process is designed to add a clinically actionable step without adding administrative burden to the case management team.
Still have questions? We'd be glad to talk through how Inagene works for your specific organization.